TF

Chr 3q22.1

transferrin

Aliases:: PRO1557, PRO2086
MANE:: ENST00000402696.9

OMIM: 190000 ↗NCBI: 7018 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TF · P02787

v62025-08-01

Predicted Aligned Error matrix for TF — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

93.1/ 100

Very high

698 residues

Confidence breakdown

Very high(≥ 90)85%
Confident(70–90)11%
Low(50–70)1%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cytopenias and congenital anaemias
BIALLELIC, autosomal or pseudoautosomal
Iron metabolism disorders - NOT common HFE mutations
BIALLELIC, autosomal or pseudoautosomal
Rare anaemia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

atransferrinemia
0.76
Congenital atransferrinemia
0.66
hemochromatosis type 1
0.47
alcohol drinking
0.46
neurodegenerative disease
0.40
urolithiasis
0.29
preeclampsia
0.24
prostate cancer
0.13
Familial prostate cancer
0.13
Iron deficiency anemia
0.13

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serotransferrin

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation