TFG

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Childhood onset hereditary spastic paraplegia

  BIALLELIC, autosomal or pseudoautosomal

• Hereditary neuropathy

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Hereditary neuropathy or pain disorder

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Hereditary spastic paraplegia

  BIALLELIC, autosomal or pseudoautosomal

• Intellectual disability

  BIALLELIC, autosomal or pseudoautosomal

• Optic neuropathy

  BIALLELIC, autosomal or pseudoautosomal

• Adult onset hereditary spastic paraplegia

  BIALLELIC, autosomal or pseudoautosomal

• Adult onset neurodegenerative disorder

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• Autosomal recessive spastic paraplegia type 57

  0.78

• hereditary motor and sensory neuropathy, Okinawa type

  0.73

• hereditary spastic paraplegia 57

  0.73

• autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation

  0.58

• cancer

  0.57

• neurodegenerative disease

  0.55

• hereditary disease

  0.41

• anaplastic large cell lymphoma

  0.38

• thyroid gland papillary carcinoma

  0.37

• lung adenocarcinoma

  0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)