TFPI

Chr 2q32.1

tissue factor pathway inhibitor

Aliases:: EPI, TFI, TFPI1
MANE:: ENST00000233156.9

OMIM: 152310 ↗NCBI: 7035 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

TFPI · P10646

v62025-08-01

Predicted Aligned Error matrix for TFPI — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.6/ 100

Confident

304 residues

Confidence breakdown

Very high(≥ 90)48%
Confident(70–90)11%
Low(50–70)13%
Very low(< 50)29%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Thrombophilia with a likely monogenic cause
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Inherited bleeding disorders

Disease associations (Open Targets)

hemophilia B
0.53
hemorrhage
0.53
hemophilia
0.51
hemophilia A
0.46
neurodegenerative disease
0.37
hemorrhagic disease
0.36
myocardial infarction
0.32
Alzheimer disease
0.32
multiple sclerosis
0.32
Parkinson disease
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tissue factor pathway inhibitor

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma