AlphaFold predicted structure
TG · P01266
Mean pLDDT
Not published
AlphaFold has not published a prediction for this sequence. This is common for very long proteins.
Confidence breakdown
Check AlphaFold DB
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TG
Chr 8q24.22thyroglobulin
- Aliases:
- TGN, AITD3
- MANE:
- ENST00000220616.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Congenital hypothyroidism
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalInherited non-medullary thyroid cancer
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
hypothyroidism
0.76familial thyroid dyshormonogenesis
0.71Hashimoto thyroiditis
0.70thyroid gland disorder
0.66congenital hypothyroidism
0.63nodular goiter
0.60nontoxic goiter
0.55multinodular goiter
0.54toxic multinodular goitre
0.52thyroid gland carcinoma
0.51
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Thyroglobulin
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:17532758, PubMed:32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030)
Diseases associated with TG
Curated MONDO disease pages that list TG among their top associated genes.