THPO

Chr 3q27.1

thrombopoietin

Aliases:: TPO, MPLLG
MANE:: ENST00000647395.1

OMIM: 600044 ↗NCBI: 7066 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

THPO · P40225

v62025-08-01

Predicted Aligned Error matrix for THPO — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

61.4/ 100

Low

353 residues

Confidence breakdown

Very high(≥ 90)23%
Confident(70–90)20%
Low(50–70)7%
Very low(< 50)51%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Inherited bleeding disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Thrombocythaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Skeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
VACTERL-like phenotypes

Disease associations (Open Targets)

thrombocythemia 1
0.68
amegakaryocytic thrombocytopenia, congenital, 2
0.53
thrombocytopenia 9
0.51
Thrombocytopenia
0.50
congenital amegakaryocytic thrombocytopenia 1
0.47
congenital amegakaryocytic thrombocytopenia
0.47
thrombocytopenia 4
0.41
hereditary disease
0.41
familial thrombocytosis
0.38
essential thrombocythemia
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Thrombopoietin

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets