AlphaFold predicted structure
THSD1 · Q9NS62
Mean pLDDT
59.1/ 100
Low
852 residues
Confidence breakdown
- Very high(≥ 90)14%
- Confident(70–90)25%
- Low(50–70)13%
- Very low(< 50)49%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
THSD1
Chr 13q14.3thrombospondin type 1 domain containing 1
- Aliases:
- TMTSP
- MANE:
- ENST00000258613.5
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomalCerebral vascular malformations
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
aneurysm, intracranial berry, 12
0.70lymphatic malformation 13
0.58Non-immune hydrops fetalis
0.45neurodegenerative disease
0.38Familial cerebral saccular aneurysm
0.37Alzheimer disease
0.24subarachnoid hemorrhage
0.19aortic aneurysm
0.12vascular dementia
0.11Blackfan-Diamond anemia
0.04
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Thrombospondin type-1 domain-containing protein 1
Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix