THSD4

Chr 15q23

thrombospondin type 1 domain containing 4

Aliases:: FVSY9334, PRO34005, FLJ13710, ADAMTSL6
MANE:: ENST00000261862.8

OMIM: 614476 ↗NCBI: 79875 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

THSD4 · Q6ZMP0

v62025-08-01

Predicted Aligned Error matrix for THSD4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

66.8/ 100

Low

1,018 residues

Confidence breakdown

Very high(≥ 90)14%
Confident(70–90)45%
Low(50–70)7%
Very low(< 50)34%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Thoracic aortic aneurysm or dissection (GMS)
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

aortic aneurysm, familial thoracic 12
0.58
familial thoracic aortic aneurysm and aortic dissection
0.48
chronic obstructive pulmonary disease
0.46
Abnormality of the skeletal system
0.46
Microscopic hematuria
0.38
Hematuria
0.37
lower respiratory tract disorder
0.37
open-angle glaucoma
0.34
glaucoma
0.33
Rare disease with thoracic aortic aneurysm and aortic dissection
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Thrombospondin type-1 domain-containing protein 4

Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN