TIMM22

Chr 17p13

translocase of inner mitochondrial membrane 22

Aliases:: TIM22
MANE:: ENST00000327158.5

OMIM: 607251 ↗NCBI: 29928 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

TIMM22 · Q9Y584

v62025-08-01

Predicted Aligned Error matrix for TIMM22 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.4/ 100

Confident

194 residues

Confidence breakdown

Very high(≥ 90)45%
Confident(70–90)26%
Low(50–70)19%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Mitochondrial disorders
BIALLELIC, autosomal or pseudoautosomal
Possible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

combined oxidative phosphorylation deficiency 43
0.50
crush injury
0.05
shoulder fracture
0.04
vitiligo
0.04
clavicle fracture
0.04
parasitic infectious disease
0.04
femoral neck fracture
0.03
isolated hyperchlorhidrosis
0.03
alcohol drinking
0.03
pseudohypoaldosteronism, type IB2, autosomal recessive
0.03

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mitochondrial import inner membrane translocase subunit Tim22

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity)