TIRAP

Chr 11q24.2

TIR domain containing adaptor protein

Aliases:: Mal, wyatt
MANE:: ENST00000392679.6

OMIM: 606252 ↗NCBI: 114609 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TIRAP · P58753

v62025-08-01

Predicted Aligned Error matrix for TIRAP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.9/ 100

Confident

221 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)10%
Low(50–70)8%
Very low(< 50)30%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

inborn error of immunity
0.37
neurodegenerative disease
0.23
Sepsis
0.08
non-small cell lung carcinoma
0.08
hepatocellular carcinoma
0.07
tuberculosis
0.06
response to statin
0.06
systemic lupus erythematosus
0.06
nephritis
0.05
myelodysplastic syndrome
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Toll/interleukin-1 receptor domain-containing adapter protein

Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF (TNF) and interleukin-6 (IL6)