AlphaFold predicted structure
TLR3 · O15455
Mean pLDDT
90.6/ 100
Very high
904 residues
Confidence breakdown
- Very high(≥ 90)75%
- Confident(70–90)17%
- Low(50–70)4%
- Very low(< 50)4%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TLR3
Chr 4q35.1toll like receptor 3
- Aliases:
- CD283
- MANE:
- ENST00000296795.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomalFamilial Meniere Disease
Disease associations (Open Targets)
Herpetic encephalitis
0.62hypothyroidism
0.57thyroid gland disorder
0.54Hashimoto thyroiditis
0.46myxedema
0.46HIV-1 infection
0.40inborn error of immunity
0.37autoimmune disease
0.37autoimmune thyroid disease
0.37basal cell carcinoma
0.36
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Toll-like receptor 3
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response
Diseases associated with TLR3
Curated MONDO disease pages that list TLR3 among their top associated genes.