toll like receptor 7
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Diagnostic Grade (Green)
COVID-19 research
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesPrimary immunodeficiency or monogenic inflammatory bowel disease
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)Familial Meniere Disease
systemic lupus erythematosus
rheumatoid arthritis
immunodeficiency 74, COVID-19-related, X-linked
actinic keratosis
systemic lupus erythematosus 17
basal cell carcinoma
malaria
keratosis
anogenital human papillomavirus infection
cutaneous lupus erythematosus
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Toll-like receptor 7
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:12738885, PubMed:27742543, PubMed:31608988, PubMed:32706371, PubMed:35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371). In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state
Curated MONDO disease pages that list TLR7 among their top associated genes.
TLR7 · Q9NYK1
Mean pLDDT
87.6/ 100
Confident
1,049 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
