toll like receptor 8
Annotations refreshed 9 hours ago.
Diagnostic Grade (Green)
Primary immunodeficiency or monogenic inflammatory bowel disease
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)Familial Meniere Disease
Intellectual disability
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)immunodeficiency 98 with autoinflammation, X-linked
osteoarthritis
autoimmune hemolytic anemia
Systemic autoinflammation
lupus erythematosus
autoimmune disorder of central nervous system
systemic lupus erythematosus
neoplasm
common wart
primary cutaneous T-cell non-Hodgkin lymphoma
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Toll-like receptor 8
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses (PubMed:33718825). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:33718825). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428)
TLR8 · Q9NR97
Mean pLDDT
86.1/ 100
Confident
1,041 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
