TMC6

Chr 17q25.3

transmembrane channel like 6

Aliases:: LAK-4P, EVIN1
MANE:: ENST00000590602.6

OMIM: 605828 ↗NCBI: 11322 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TMC6 · Q7Z403

v62025-08-01

Predicted Aligned Error matrix for TMC6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.3/ 100

Confident

805 residues

Confidence breakdown

Very high(≥ 90)24%
Confident(70–90)43%
Low(50–70)11%
Very low(< 50)22%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Epidermodysplasia verruciformis
BIALLELIC, autosomal or pseudoautosomal
Pigmentary skin disorders
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Multiple monogenic benign skin tumours
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

epidermodysplasia verruciformis
0.75
hereditary disease
0.19
response to xenobiotic stimulus
0.15
hypertensive disorder
0.15
Abnormality of the skeletal system
0.09
type 2 diabetes mellitus
0.08
diabetes mellitus
0.08
homozygous familial hypercholesterolemia
0.05
infection
0.05
Hyperlipoproteinemia type 5
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transmembrane channel-like protein 6

Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:30068544, PubMed:32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity)