TMEFF1

Chr 9q31.1

transmembrane protein with EGF like and two follistatin like domains 1

Aliases:: H7365, CT120.1
MANE:: ENST00000374879.5

OMIM: 603421 ↗NCBI: 8577 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TMEFF1 · Q8IYR6

v62025-08-01

Predicted Aligned Error matrix for TMEFF1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.0/ 100

Low

380 residues

Confidence breakdown

Very high(≥ 90)20%
Confident(70–90)30%
Low(50–70)24%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

stroke disorder
0.25
alcohol drinking
0.25
sialolithiasis
0.23
Precordial pain
0.18
ovarian carcinoma
0.10
ovarian cancer
0.10
dermatophytosis
0.09
endometrial carcinoma
0.08
cardiac hypertrophy
0.07
endometrial cancer
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tomoregulin-1

Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed:39048823, PubMed:39048830). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (PubMed:39048823). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (PubMed:39048823, PubMed:39048830). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (PubMed:39048823). May be a tumor suppressor in brain cancers (PubMed:12743596)