TMEM163

Chr 2q21.3

transmembrane protein 163

Aliases:: DKFZP566N034, SV31, SLC30A11
MANE:: ENST00000281924.6

OMIM: 618978 ↗NCBI: 81615 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TMEM163 · Q8TC26

v62025-08-01

Predicted Aligned Error matrix for TMEM163 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.5/ 100

Confident

289 residues

Confidence breakdown

Very high(≥ 90)39%
Confident(70–90)27%
Low(50–70)18%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

leukodystrophy, hypomyelinating, 25
0.55
primary biliary cholangitis
0.43
Parkinson disease
0.43
hair color
0.42
mathematical ability
0.38
placenta praevia
0.29
COVID-19
0.29
spermatogenic failure
0.29
attention deficit-hyperactivity disorder
0.29
substance abuse
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transmembrane protein 163

Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965)