TMEM17

Chr 2p15

transmembrane protein 17

Aliases:: FLJ34583
MANE:: ENST00000335390.6

OMIM: 614950 ↗NCBI: 200728 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

TMEM17 · Q86X19

v62025-08-01

Predicted Aligned Error matrix for TMEM17 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.8/ 100

Confident

198 residues

Confidence breakdown

Very high(≥ 90)61%
Confident(70–90)25%
Low(50–70)8%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Cystic kidney disease
BIALLELIC, autosomal or pseudoautosomal
Limb disorders
BIALLELIC, autosomal or pseudoautosomal
Neurological ciliopathies
BIALLELIC, autosomal or pseudoautosomal
Renal ciliopathies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

prostate carcinoma
0.51
prostate cancer
0.42
smoking cessation
0.39
Urinary incontinence
0.39
substance-related disorder
0.38
ciliopathy
0.38
Meckel syndrome
0.33
nicotine dependence
0.31
mathematical ability
0.30
neurodegenerative disease
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transmembrane protein 17

Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity)