TMEM222

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• DDG2P

  BIALLELIC, autosomal or pseudoautosomal

• Early onset or syndromic epilepsy

  BIALLELIC, autosomal or pseudoautosomal

• Intellectual disability

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• neurodevelopmental disorder with motor and speech delay and behavioral abnormalities

  0.69

• complex neurodevelopmental disorder

  0.37

• hereditary disease

  0.19

• neurodevelopmental disorder

  0.01

• breast cancer

  0.00

• Intellectual disability

  0.00

• ovarian serous cystadenocarcinoma

  0.00

• clear cell renal carcinoma

  0.00

• cervical cancer

  0.00

• esophageal cancer

  0.00

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.