TMEM260

Chr 14q22.3

transmembrane protein 260

Aliases:: FLJ20392
MANE:: ENST00000261556.11

OMIM: 617449 ↗NCBI: 54916 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

TMEM260 · Q9NX78

v62025-08-01

Predicted Aligned Error matrix for TMEM260 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.4/ 100

Very high

707 residues

Confidence breakdown

Very high(≥ 90)85%
Confident(70–90)11%
Low(50–70)2%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

CAKUT
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Paediatric disorders - additional genes
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

structural heart defects and renal anomalies syndrome
0.74
Ulbright-Hodes syndrome
0.64
alcohol drinking
0.35
Type I truncus arteriosus
0.34
osteoarthritis, hip
0.30
mastodynia
0.29
arthropathy
0.29
urolithiasis
0.29
DNA methylation
0.28
inflammatory bowel disease
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein O-mannosyl-transferase TMEM260

O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins (PubMed:37186866). Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON (PubMed:37186866). TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified (PubMed:37186866)