TMEM263

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• aging

  0.36

• non-neoplastic bile duct disorder

  0.28

• osteoarthritis

  0.24

• placental abruption

  0.22

• skeletal dysplasia

  0.19

• influenza A (H1N1)

  0.12

• irritable bowel syndrome

  0.10

• Hypocalcemic vitamin D-resistant rickets

  0.05

• Hypocalcemic vitamin D-dependent rickets

  0.05

• Berardinelli-Seip congenital lipodystrophy

  0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)