TMEM98

Chr 17q11.2

transmembrane protein 98

Aliases:: DKFZP564K1964
MANE:: ENST00000579849.6

OMIM: 615949 ↗NCBI: 26022 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TMEM98 · Q9Y2Y6

v62025-08-01

Predicted Aligned Error matrix for TMEM98 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.0/ 100

Confident

226 residues

Confidence breakdown

Very high(≥ 90)20%
Confident(70–90)41%
Low(50–70)18%
Very low(< 50)22%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Anophthalmia or microphthalmia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

nanophthalmia
0.71
microphthalmia
0.70
nephrotic syndrome
0.29
Abnormality of refraction
0.24
myopia
0.24
Dupuytren Contracture
0.23
refractive error
0.22
hereditary disease
0.19
primary angle-closure glaucoma
0.16
Hypermetropia
0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transmembrane protein 98

Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1)