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TMPRSS2

Chr 21q22.3

transmembrane serine protease 2

Aliases:
PRSS10
MANE:
ENST00000332149.10
OMIM: 602060 ↗NCBI: 7113 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

  • COVID-19 research

    Unknown

Disease associations (Open Targets)

  • COVID-19

    0.61

  • prostate carcinoma

    0.60

  • prostate cancer

    0.49

  • prostate adenocarcinoma

    0.45

  • severe acute respiratory syndrome

    0.38

  • prostate small cell carcinoma

    0.38

  • prostate intraepithelial neoplasia

    0.38

  • benign prostatic hyperplasia

    0.37

  • grade III prostatic intraepithelial neoplasia

    0.37

  • acinar prostate mucinous adenocarcinoma

    0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transmembrane protease serine 2

Plasma membrane-anchored serine protease that cleaves at arginine residues (PubMed:32703818, PubMed:35676539, PubMed:37990007, PubMed:38964328). Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:25122198, PubMed:26018085). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity)

Diseases associated with TMPRSS2

Curated MONDO disease pages that list TMPRSS2 among their top associated genes.

Data sources: HGNC (CC BY 4.0), AlphaFold (CC BY 4.0, Jumper et al. Nature 2021), Genomics England PanelApp (CC BY 4.0), ClinGen, Open Targets (CC0), UniProt.

Not for sole clinical decision-making. Always verify against primary sources.