TMX3

Chr 18q22.1

thioredoxin related transmembrane protein 3

Aliases:: FLJ20793, KIAA1830, PDIA13
MANE:: ENST00000299608.7

OMIM: 616102 ↗NCBI: 54495 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

TMX3 · Q96JJ7

v62025-08-01

Predicted Aligned Error matrix for TMX3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.3/ 100

Confident

454 residues

Confidence breakdown

Very high(≥ 90)64%
Confident(70–90)18%
Low(50–70)7%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

postinflammatory pulmonary fibrosis
0.29
endocarditis
0.28
liver disorder
0.27
acquired thrombocytopenia
0.22
response to antibiotic
0.19
response to xenobiotic stimulus
0.19
poisoning
0.19
Abnormality of the skeletal system
0.17
preeclampsia
0.16
memory impairment
0.16

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein disulfide-isomerase TMX3

Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (PubMed:15623505). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:31304984)