AlphaFold predicted structure
TNC · P24821
Mean pLDDT
74.9/ 100
Confident
2,201 residues
Confidence breakdown
- Very high(≥ 90)9%
- Confident(70–90)64%
- Low(50–70)21%
- Very low(< 50)7%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TNC
Chr 9q33.1tenascin C
- Aliases:
- TN, MGC167029
- MANE:
- ENST00000350763.9
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Monogenic hearing loss
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
autosomal dominant nonsyndromic hearing loss
0.62deafness
0.55osteoarthritis, hip
0.51Dupuytren Contracture
0.44Abnormality of the skeletal system
0.43total hip arthroplasty
0.43medical procedure
0.39osteoarthritis, knee
0.39osteoarthritis
0.37vein disorder
0.36
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Tenascin
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327)
Diseases associated with TNC
Curated MONDO disease pages that list TNC among their top associated genes.