TNFRSF11A

Chr 18q21.33

TNF receptor superfamily member 11a

Aliases:: RANK, CD265, FEO, ODFR, TRANCE-R
MANE:: ENST00000586569.3

OMIM: 603499 ↗NCBI: 8792 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TNFRSF11A · Q9Y6Q6

v62025-08-01

Predicted Aligned Error matrix for TNFRSF11A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.9/ 100

Low

616 residues

Confidence breakdown

Very high(≥ 90)27%
Confident(70–90)8%
Low(50–70)10%
Very low(< 50)55%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Hydrocephalus
BIALLELIC, autosomal or pseudoautosomal
Osteopetrosis
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Skeletal dysplasia
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Childhood solid tumours
Osteogenesis imperfecta

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Disease associations (Open Targets)

Osteopetrosis - hypogammaglobulinemia
0.75
autosomal recessive osteopetrosis 7
0.71
familial expansile osteolysis
0.65
bone Paget disease
0.61
osteoporosis
0.53
bone disorder
0.44
asthma
0.44
hypothyroidism
0.44
allergic rhinitis
0.42
osteopetrosis
0.42

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tumor necrosis factor receptor superfamily member 11A

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity)