TNFRSF11B

Chr 8q24.12

TNF receptor superfamily member 11b

Aliases:: OCIF, TR1
MANE:: ENST00000297350.9

OMIM: 602643 ↗NCBI: 4982 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TNFRSF11B · O00300

v62025-08-01

Predicted Aligned Error matrix for TNFRSF11B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.5/ 100

Confident

401 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)34%
Low(50–70)5%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Monogenic hearing loss

Disease associations (Open Targets)

juvenile Paget disease
0.70
osteoporosis
0.47
hypothyroidism
0.47
myxedema
0.38
nasal cavity polyp
0.37
bone fracture
0.34
bone disorder
0.32
autoimmune disease
0.30
thyroid gland disorder
0.27
Hashimoto thyroiditis
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tumor necrosis factor receptor superfamily member 11B

Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis