TNFRSF13B

Chr 17p11.2

TNF receptor superfamily member 13B

Aliases:: TACI, CD267, IGAD2
MANE:: ENST00000261652.7

OMIM: 604907 ↗NCBI: 23495 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TNFRSF13B · O14836

v62025-08-01

Predicted Aligned Error matrix for TNFRSF13B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.5/ 100

Low

293 residues

Confidence breakdown

Very high(≥ 90)13%
Confident(70–90)23%
Low(50–70)23%
Very low(< 50)41%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency, common variable, 2
0.80
immunoglobulin A deficiency 2
0.70
common variable immunodeficiency
0.70
plasma cell myeloma
0.56
monoclonal gammopathy
0.47
immunodeficiency, common variable, 1
0.47
recurrent infections associated with rare immunoglobulin isotypes deficiency
0.46
Paraproteinemia
0.44
amino acid metabolism disease
0.43
plasma protein metabolism disease
0.43

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tumor necrosis factor receptor superfamily member 13B

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity