TNFRSF13C

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• COVID-19 research

  BIALLELIC, autosomal or pseudoautosomal

• Primary immunodeficiency or monogenic inflammatory bowel disease

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• immunodeficiency, common variable, 4

  0.63

• common variable immunodeficiency

  0.44

• recurrent infections associated with rare immunoglobulin isotypes deficiency

  0.42

• systemic lupus erythematosus

  0.37

• Sjogren syndrome

  0.37

• autoimmune thrombocytopenic purpura

  0.35

• lupus nephritis

  0.33

• autoimmune hemolytic anemia

  0.26

• autoimmune hepatitis

  0.19

• immunodeficiency, common variable, 2

  0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)