TNFRSF4

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• COVID-19 research

  BIALLELIC, autosomal or pseudoautosomal

• Primary immunodeficiency or monogenic inflammatory bowel disease

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• combined immunodeficiency due to OX40 deficiency

  0.52

• atopic eczema

  0.41

• combined immunodeficiency

  0.37

• severe combined immunodeficiency

  0.37

• prurigo nodularis

  0.26

• neurodegenerative disease

  0.20

• neoplasm

  0.13

• asthma

  0.13

• acute myeloid leukemia

  0.12

• infection

  0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)