TNFRSF9

Chr 1p36.23

TNF receptor superfamily member 9

Aliases:: CD137, 4-1BB
MANE:: ENST00000377507.8

OMIM: 602250 ↗NCBI: 3604 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TNFRSF9 · Q07011

v62025-08-01

Predicted Aligned Error matrix for TNFRSF9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.0/ 100

Confident

255 residues

Confidence breakdown

Very high(≥ 90)55%
Confident(70–90)18%
Low(50–70)19%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency 109 with lymphoproliferation
0.52
hair color
0.24
chronic venous hypertension
0.24
hereditary disease
0.19
total joint arthroplasty
0.15
osteoarthritis, hip
0.15
osteoarthritis, knee
0.15
diffuse large B-cell lymphoma
0.14
breast cancer
0.12
melanoma
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tumor necrosis factor receptor superfamily member 9

Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable)