TNFSF10

Chr 3q26.31

TNF superfamily member 10

Aliases:: TRAIL, Apo-2L, TL2, CD253, TANCR
MANE:: ENST00000241261.7

OMIM: 603598 ↗NCBI: 8743 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TNFSF10 · P50591

v62025-08-01

Predicted Aligned Error matrix for TNFSF10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.7/ 100

Confident

281 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)20%
Low(50–70)18%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

gout
0.44
breast carcinoma
0.42
triple-negative breast carcinoma
0.38
cholelithiasis
0.36
luminal A breast carcinoma
0.36
prostate carcinoma
0.35
pericarditis
0.24
chronic laryngitis
0.22
renal carcinoma
0.20
glioblastoma
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tumor necrosis factor ligand superfamily member 10

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis

Curated MONDO disease pages that list TNFSF10 among their top associated genes.

pancreatic neoplasmRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with TNFSF10