TNF superfamily member 11
Annotations refreshed 9 hours ago.
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalOsteopetrosis
BIALLELIC, autosomal or pseudoautosomalSkeletal dysplasia
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalosteoporosis
autosomal recessive osteopetrosis 2
Autosomal recessive malignant osteopetrosis
bone neoplasm
postmenopausal osteoporosis
bone giant cell tumor
bone resorption
bone disorder
giant cell tumor
plasma cell myeloma
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Tumor necrosis factor ligand superfamily member 11
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity)
TNFSF11 · O14788
Mean pLDDT
79.2/ 100
Confident
317 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
