TNFSF12

Chr 17p13.1

TNF superfamily member 12

Aliases:: TWEAK, DR3LG, APO3L, TNF12
MANE:: ENST00000293825.11

OMIM: 602695 ↗NCBI: 8742 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TNFSF12 · O43508

v62025-08-01

Predicted Aligned Error matrix for TNFSF12 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.9/ 100

Confident

249 residues

Confidence breakdown

Very high(≥ 90)49%
Confident(70–90)16%
Low(50–70)18%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

atrial fibrillation
0.40
hypertensive disorder
0.39
eyelid disorder
0.32
neurodegenerative disease
0.27
cardioembolic stroke
0.26
osteoarthritis, hip
0.26
total hip arthroplasty
0.25
pyogenic granuloma
0.22
common variable immunodeficiency
0.21
testicular disorder
0.17

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tumor necrosis factor ligand superfamily member 12

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion