TNIK

Chr 3q26.2-q26.31

TRAF2 and NCK interacting kinase

Aliases:: MAP4K7, KIAA0551
MANE:: ENST00000436636.7

OMIM: 610005 ↗NCBI: 23043 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TNIK · Q9UKE5

v62025-08-01

Predicted Aligned Error matrix for TNIK — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

63.6/ 100

Low

1,360 residues

Confidence breakdown

Very high(≥ 90)22%
Confident(70–90)30%
Low(50–70)6%
Very low(< 50)43%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.53
autosomal recessive non-syndromic intellectual disability
0.51
Abnormality of the skeletal system
0.49
alcohol drinking
0.36
Myoclonus
0.32
dyshidrosis
0.30
sweat gland disorder
0.30
humerus fracture
0.30
liver disorder
0.29
ocular hypotension
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

TRAF2 and NCK-interacting protein kinase

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443)