TNK2

Chr 3q29

tyrosine kinase non receptor 2

Aliases:: p21cdc42Hs, ACK, ACK1
MANE:: ENST00000672887.2

OMIM: 606994 ↗NCBI: 10188 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

TNK2 · Q07912

v62025-08-01

Predicted Aligned Error matrix for TNK2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

61.3/ 100

Low

1,038 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)11%
Low(50–70)10%
Very low(< 50)49%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Parkinson disease
0.38
gout
0.38
infantile-onset mesial temporal lobe epilepsy with severe cognitive regression
0.37
Epileptic encephalopathy
0.33
Abnormality of the skeletal system
0.33
Abnormal nasolacrimal system morphology
0.31
Alzheimer disease
0.23
neurodegenerative disease
0.23
multiple sclerosis
0.23
lysosomal storage disease
0.23

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Activated CDC42 kinase 1

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370)