AlphaFold predicted structure
TNNC1 · P63316
Mean pLDDT
79.9/ 100
Confident
161 residues
Confidence breakdown
- Very high(≥ 90)1%
- Confident(70–90)86%
- Low(50–70)10%
- Very low(< 50)4%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TNNC1
Chr 3p21.1troponin C1, slow skeletal and cardiac type
- MANE:
- ENST00000232975.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Dilated and arrhythmogenic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedDilated Cardiomyopathy and conduction defects
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedHypertrophic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPaediatric or syndromic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedHereditary neuropathy
Hereditary neuropathy or pain disorder
Disease associations (Open Targets)
dilated cardiomyopathy 1Z
0.77hypertrophic cardiomyopathy
0.77hypertrophic cardiomyopathy 13
0.72familial isolated dilated cardiomyopathy
0.67Rare familial disorder with hypertrophic cardiomyopathy
0.49neurodegenerative disease
0.44dilated cardiomyopathy
0.42heart failure
0.40congestive heart failure
0.37cardiovascular disorder
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Troponin I, cardiac muscle
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Diseases associated with TNNC1
Curated MONDO disease pages that list TNNC1 among their top associated genes.