TNNI3

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Dilated and arrhythmogenic cardiomyopathy

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Dilated Cardiomyopathy and conduction defects

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Hypertrophic cardiomyopathy

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Paediatric or syndromic cardiomyopathy

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Hereditary neuropathy

• Hereditary neuropathy or pain disorder

• Left Ventricular Noncompaction Cardiomyopathy

Disease associations (Open Targets)

• hypertrophic cardiomyopathy

  0.83

• cardiomyopathy, familial restrictive, 1

  0.78

• dilated cardiomyopathy 1FF

  0.78

• dilated cardiomyopathy 2A

  0.76

• hypertrophic cardiomyopathy 7

  0.74

• familial isolated dilated cardiomyopathy

  0.72

• Rare familial disorder with hypertrophic cardiomyopathy

  0.69

• familial isolated restrictive cardiomyopathy

  0.60

• cardiomyopathy

  0.58

• Abnormality of the cardiovascular system

  0.56

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with TNNI3

Curated MONDO disease pages that list TNNI3 among their top associated genes.

• hypertrophic cardiomyopathyRare
• familial isolated dilated cardiomyopathyRare