TNNI3K

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Dilated and arrhythmogenic cardiomyopathy

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Paediatric or syndromic cardiomyopathy

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Progressive cardiac conduction disease

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Non-syndromic familial congenital anorectal malformations

Disease associations (Open Targets)

• atrial conduction disease

  0.76

• Abnormality of the cardiovascular system

  0.46

• neurodegenerative disease

  0.33

• Arrhythmogenic right ventricular dysplasia

  0.28

• alcohol drinking

  0.24

• placenta praevia

  0.24

• Abnormality of the skeletal system

  0.24

• dilated cardiomyopathy

  0.23

• stroke disorder

  0.23

• smoking initiation

  0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)