TNNT1

Chr 19q13.42

troponin T1, slow skeletal type

Aliases:: ANM, STNT, TNT, TNTS, FLJ98147
MANE:: ENST00000588981.6

OMIM: 191041 ↗NCBI: 7138 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TNNT1 · P13805

v62025-08-01

Predicted Aligned Error matrix for TNNT1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.1/ 100

Confident

278 residues

Confidence breakdown

Very high(≥ 90)39%
Confident(70–90)19%
Low(50–70)25%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal
Congenital myopathy
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

nemaline myopathy 5
0.77
nemaline myopathy 5B, autosomal recessive, childhood-onset
0.66
nemaline myopathy 5C, autosomal dominant
0.62
Amish nemaline myopathy
0.47
nemaline myopathy
0.39
autosomal recessive nemaline myopathy
0.37
Thrombocytopenia
0.30
hereditary disease
0.19
myopathy
0.13
amyotrophic lateral sclerosis
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Troponin T, slow skeletal muscle

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity