TNRC6B

Chr 22q13.1

trinucleotide repeat containing adaptor 6B

Aliases:: KIAA1093
MANE:: ENST00000454349.7

OMIM: 610740 ↗NCBI: 23112 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TNRC6B · Q9UPQ9

v62025-08-01

Predicted Aligned Error matrix for TNRC6B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

39.1/ 100

Very low

1,833 residues

Confidence breakdown

Very high(≥ 90)5%
Confident(70–90)3%
Low(50–70)3%
Very low(< 50)89%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

global developmental delay with speech and behavioral abnormalities
0.74
hereditary disease
0.54
complex neurodevelopmental disorder
0.46
autism spectrum disorder
0.42
Global developmental delay
0.41
Autistic behavior
0.41
neurodevelopmental disorder
0.40
uterine corpus leiomyoma
0.39
Abnormality of the skeletal system
0.38
alcohol drinking
0.38

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Trinucleotide repeat-containing gene 6B protein

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923)