AlphaFold predicted structure
TOMM7 · Q9P0U1
Mean pLDDT
92.8/ 100
Very high
55 residues
Confidence breakdown
- Very high(≥ 90)87%
- Confident(70–90)9%
- Low(50–70)4%
- Very low(< 50)0%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
TOMM7
Chr 7p15.3translocase of outer mitochondrial membrane 7
- Aliases:
- Tom7
- MANE:
- ENST00000358435.9
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomalSkeletal dysplasia
BIALLELIC, autosomal or pseudoautosomalStructural eye disease
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Garg-Mishra progeroid syndrome
0.73type 2 diabetes mellitus
0.40response to BCG intravesical immunotherapy
0.31diabetes mellitus
0.31COVID-19
0.31arthropathy
0.11asthma
0.09ovarian dysfunction
0.09acquired polycythemia vera
0.05cervical carcinoma
0.04
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Mitochondrial import receptor subunit TOM7 homolog
Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546)