TOMM70

Chr 3q12.2

translocase of outer mitochondrial membrane 70

Aliases:: KIAA0719, Tom70
MANE:: ENST00000284320.6

OMIM: 606081 ↗NCBI: 9868 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TOMM70 · O94826

v62025-08-01

Predicted Aligned Error matrix for TOMM70 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.1/ 100

Confident

608 residues

Confidence breakdown

Very high(≥ 90)62%
Confident(70–90)16%
Low(50–70)2%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Mitochondrial disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

severe acute respiratory syndrome
0.46
COVID-19
0.37
poisoning
0.25
Global developmental delay
0.23
Abnormal cerebral white matter morphology
0.23
hereditary disease
0.18
Abnormal nasolacrimal system morphology
0.08
Alzheimer disease
0.07
colorectal carcinoma
0.05
ovarian neoplasm
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mitochondrial import receptor subunit TOM70

Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812)

Curated MONDO disease pages that list TOMM70 among their top associated genes.

severe acute respiratory syndromeRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with TOMM70