TP73

Chr 1p36.32

tumor protein p73

Aliases:: P73
MANE:: ENST00000378295.9

OMIM: 601990 ↗NCBI: 7161 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TP73 · O15350

v62025-08-01

Predicted Aligned Error matrix for TP73 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

65.2/ 100

Low

636 residues

Confidence breakdown

Very high(≥ 90)35%
Confident(70–90)14%
Low(50–70)4%
Very low(< 50)48%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Malformations of cortical development
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ciliary dyskinesia, primary, 47, and lissencephaly
0.76
neurodegenerative disease
0.53
insomnia
0.28
seborrheic keratosis
0.28
skin disorder
0.28
respiratory failure
0.26
skin cancer
0.23
actinic keratosis
0.22
hereditary disease
0.19
neurodevelopmental disorder
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tumor protein p73

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761)