AlphaFold predicted structure
TPI1 · P60174
Mean pLDDT
96.7/ 100
Very high
249 residues
Confidence breakdown
- Very high(≥ 90)95%
- Confident(70–90)4%
- Low(50–70)0%
- Very low(< 50)1%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TPI1
Chr 12p13.31triosephosphate isomerase 1
- MANE:
- ENST00000396705.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Cytopenias and congenital anaemias
BIALLELIC, autosomal or pseudoautosomalRare anaemia
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
triosephosphate isomerase deficiency
0.77Triose phosphate-isomerase deficiency
0.55neurodegenerative disease
0.37hereditary disease
0.19ovarian neoplasm
0.13neoplasm
0.10hyperinsulinemic hypoglycemia, familial, 4
0.09infection
0.08hepatocellular carcinoma
0.08hereditary spherocytosis
0.08
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Triosephosphate isomerase
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis
Diseases associated with TPI1
Curated MONDO disease pages that list TPI1 among their top associated genes.