AlphaFold predicted structure
TPM1 · P09493
Mean pLDDT
91.6/ 100
Very high
284 residues
Confidence breakdown
- Very high(≥ 90)75%
- Confident(70–90)19%
- Low(50–70)5%
- Very low(< 50)1%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TPM1
Chr 15q22.2tropomyosin 1
- MANE:
- ENST00000403994.9
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Dilated and arrhythmogenic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedDilated Cardiomyopathy and conduction defects
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedHypertrophic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedLeft Ventricular Noncompaction Cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownPaediatric or syndromic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedHereditary neuropathy
Hereditary neuropathy or pain disorder
Disease associations (Open Targets)
hypertrophic cardiomyopathy
0.81left ventricular noncompaction
0.76left ventricular noncompaction 9
0.66familial isolated dilated cardiomyopathy
0.64Rare familial disorder with hypertrophic cardiomyopathy
0.55Abnormality of the cardiovascular system
0.55cardiomyopathy
0.54dilated cardiomyopathy
0.54familial hypertrophic cardiomyopathy
0.49familial cardiomyopathy
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Tropomyosin alpha-1 chain
Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments
Diseases associated with TPM1
Curated MONDO disease pages that list TPM1 among their top associated genes.