AlphaFold predicted structure
TPM2 · P07951
Mean pLDDT
91.4/ 100
Very high
284 residues
Confidence breakdown
- Very high(≥ 90)73%
- Confident(70–90)21%
- Low(50–70)5%
- Very low(< 50)0%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TPM2
Chr 9p13.3tropomyosin 2
- Aliases:
- DA1, NEM4
- MANE:
- ENST00000645482.3
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Arthrogryposis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCongenital myopathy
BOTH monoallelic and biallelic, autosomal or pseudoautosomalDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownLimb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
congenital myopathy 23
0.81digitotalar dysmorphism
0.74cap myopathy
0.71nemaline myopathy
0.68Sheldon-hall syndrome
0.62distal arthrogryposis type 2B1
0.54distal arthrogryposis
0.46arthrogryposis, distal, type 2B4
0.45hereditary disease
0.45TPM2-related myopathy
0.44
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Tropomyosin beta chain
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization