AlphaFold predicted structure
TPM3 · P06753
Mean pLDDT
91.7/ 100
Very high
285 residues
Confidence breakdown
- Very high(≥ 90)74%
- Confident(70–90)21%
- Low(50–70)5%
- Very low(< 50)1%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TPM3
Chr 1q21.3tropomyosin 3
- Aliases:
- TRK
- MANE:
- ENST00000651641.1
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Arthrogryposis
BOTH monoallelic and biallelic, autosomal or pseudoautosomalCongenital myopathy
BOTH monoallelic and biallelic, autosomal or pseudoautosomalDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
BOTH monoallelic and biallelic, autosomal or pseudoautosomalLimb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies
BOTH monoallelic and biallelic, autosomal or pseudoautosomalPaediatric pseudo-obstruction syndrome
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
congenital fiber-type disproportion myopathy
0.82congenital myopathy 4B, autosomal recessive
0.72nemaline myopathy
0.59TPM3-related myopathy
0.49cancer
0.48cap myopathy
0.46hereditary disease
0.40anaplastic large cell lymphoma
0.38non-small cell lung carcinoma
0.38inflammatory myofibroblastic tumor
0.38
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Tropomyosin alpha-3 chain
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments