TPM4

Chr 19p13.12-p13.11

tropomyosin 4

MANE:: ENST00000643579.2

OMIM: 600317 ↗NCBI: 7171 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TPM4 · P67936

v62025-08-01

Predicted Aligned Error matrix for TPM4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

93.1/ 100

Very high

248 residues

Confidence breakdown

Very high(≥ 90)82%
Confident(70–90)13%
Low(50–70)4%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Inherited bleeding disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

bleeding disorder, platelet-type, 25
0.56
cancer
0.48
thrombocytopenia 4
0.46
hemorrhagic disease
0.40
autosomal dominant macrothrombocytopenia
0.39
inflammatory myofibroblastic tumor
0.37
lung inflammatory myofibroblastic tumor
0.37
hepatocellular carcinoma
0.21
esophageal squamous cell carcinoma
0.20
lung carcinoma
0.20

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tropomyosin alpha-4 chain

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis