AlphaFold predicted structure
TPO · P07202
Mean pLDDT
83.4/ 100
Confident
933 residues
Confidence breakdown
- Very high(≥ 90)55%
- Confident(70–90)25%
- Low(50–70)11%
- Very low(< 50)9%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TPO
Chr 2p25.3thyroid peroxidase
- Aliases:
- TPX
- MANE:
- ENST00000329066.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Congenital hypothyroidism
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
familial thyroid dyshormonogenesis
0.71hyperthyroidism
0.59hypothyroidism
0.58congenital hypothyroidism
0.54thyroid gland disorder
0.54Hashimoto thyroiditis
0.53Abnormality of the thyroid gland
0.53nodular goiter
0.49autoimmune disease
0.43autoimmune thyroid disease
0.43
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Thyroid peroxidase
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)
Diseases associated with TPO
Curated MONDO disease pages that list TPO among their top associated genes.