TPP2

Chr 13q33.1

tripeptidyl peptidase 2

Aliases:: TPPII
MANE:: ENST00000376052.5

OMIM: 190470 ↗NCBI: 7174 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

TPP2 · P29144

v62025-08-01

Predicted Aligned Error matrix for TPP2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.9/ 100

Very high

1,249 residues

Confidence breakdown

Very high(≥ 90)80%
Confident(70–90)16%
Low(50–70)1%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Adult onset leukodystrophy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency 78 with autoimmunity and developmental delay
0.76
Evans syndrome
0.66
neurodegenerative disease
0.51
Global developmental delay
0.45
Autoimmunity
0.37
atrial fibrillation
0.33
Recurrent upper respiratory tract infections
0.33
Thrombocytopenia
0.33
Cutis marmorata
0.33
Recurrent lower respiratory tract infections
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tripeptidyl-peptidase 2

Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity)