TRAK1

Chr 3p22.1

trafficking kinesin protein 1

Aliases:: OIP106, KIAA1042, MILT1
MANE:: ENST00000327628.10

OMIM: 608112 ↗NCBI: 22906 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TRAK1 · Q9UPV9

v62025-08-01

Predicted Aligned Error matrix for TRAK1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.1/ 100

Low

953 residues

Confidence breakdown

Very high(≥ 90)20%
Confident(70–90)11%
Low(50–70)17%
Very low(< 50)52%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders

Disease associations (Open Targets)

genetic developmental and epileptic encephalopathy
0.61
cancer
0.54
hereditary disease
0.42
undetermined early-onset epileptic encephalopathy
0.39
heart failure
0.29
bipolar disorder
0.26
Abnormality of the skeletal system
0.26
head and neck cancer
0.24
smoking initiation
0.15
stroke disorder
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Trafficking kinesin-binding protein 1

Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity)